ICD-10 Code A41.9 – Sepsis, Unspecified Organism
What Is ICD-10 Code A41.9?
ICD-10-CM code A41.9 is used to identify sepsis caused by an unspecified organism. It applies when a patient presents with sepsis, but the exact pathogen has not been determined. Sepsis is a life-threatening systemic response to infection that can damage tissues and organs if not treated promptly.
Table of Contents
ToggleDetailed Description of A41.9
A41.9 belongs to the “Other Sepsis” category within Chapter 1: Certain Infectious and Parasitic Diseases (A00–B99). Use this code when:
- A provider diagnoses sepsis, but no causative organism is identified.
- The condition may involve septic shock or multiple organ dysfunction syndrome (MODS).
Sepsis is clinically defined by a combination of symptoms including fever, tachycardia, tachypnea, and abnormal white blood cell counts. Early recognition and coding are critical for patient care and accurate billing.
Common Symptoms Associated with A41.9
Patients with sepsis may present with:
- High fever or hypothermia
- Rapid heartbeat (tachycardia)
- Rapid breathing (tachypnea)
- Confusion or altered mental status
- Hypotension (low blood pressure)
- Chills or shivering
- Severe pain or discomfort
- Clammy, sweaty skin
These systemic signs require urgent clinical intervention.
Related and Similar ICD-10 Codes
When the causative organism is known, use the more specific ICD-10 codes instead of A41.9:
| ICD-10 Code | Description |
|---|---|
| A40.0 | Sepsis due to Streptococcus, group A |
| A40.1 | Sepsis due to Streptococcus, group B |
| A41.0 | Sepsis due to Staphylococcus aureus |
| A41.1 | Sepsis due to other specified Staphylococcus |
| A41.2 | Sepsis due to unspecified Staphylococcus |
| A41.3 | Sepsis due to Haemophilus influenzae |
| A41.4 | Sepsis due to anaerobes |
| A41.5 | Sepsis due to other Gram-negative organisms |
Proper Usage Guidelines for A41.9
When coding A41.9, keep the following in mind:
- Only use when the pathogen is unknown.
- Document clinical criteria supporting the sepsis diagnosis.
- If sepsis occurs alongside a localized infection, code A41.9 first, then code the infection as secondary.
- Include additional codes for complications, such as:
- Septic shock: R65.21
- Acute kidney failure: N17.9
- The term “septicemia” is also mapped to this code.
- Follow CMS and ICD-10-CM official coding guidelines to ensure compliance.
Common Pitfalls When Using A41.9
- Using A41.9 when the organism is known (use a specific sepsis code instead).
- Failing to document supporting clinical evidence, which may cause claim denials.
- Omitting associated complications like acute organ dysfunction.
Key Resources for Accurate Coding
- ICD-10 Data: Comprehensive code definitions and updates
- CMS ICD-10 Guidelines: Official coding rules and policies
- CareCloud ICD and CPT Coding Guide: Practical coding guidance
- Hospital vs. Physician Coding Differences: Insights into facility vs. professional coding
Summary
ICD-10-CM A41.9 is essential for coding sepsis without a confirmed organism. Accurate documentation, proper sequencing, and awareness of related codes are crucial to ensure correct billing and patient care. By understanding the clinical criteria, associated symptoms, and coding pitfalls, healthcare providers can confidently apply A41.9 in daily practice.
Stay compliant and precise: always follow the latest CMS and ICD-10-CM guidelines and document thoroughly to optimize coding accuracy.




